FORMULATION AND EVALUATION OF SELF DOUBLE EMULSIFYING DRUG DELIVERY SYSTEMS OF TAMOXIFEN

Abstract

Indeed, the instability of multiple emulsions poses a challenge for commercial use. However, their capacity to enhance oral absorption, especially for medications with high solubility and limited permeability, highlights a promising avenue for pharmaceutical applications. Balancing stability concerns with enhanced drug delivery remains a key focus in this area of research. Optimizing the formulation of a SDEDDS by incorporating water-in-oil (w/o) surfactants that attract water emulsion is a promising strategy. This approach can lead to enhanced stability, particularly in the context of testing solubility for drugs like Tamoxifen across various solvents. Such advancements contribute to the development of more effective DDS . The construction of a pseudo-ternary phase diagram is a valuable tool for the micro-emulsion zone's identification. By adjusting oil, surfactant, and co-surfactant concentrations eight distinct formulations were created. This systematic approach aids in understanding the optimal composition for achieving stable micro-emulsions in pharmaceutical or industrial applications. Formulation F7, optimized through Zeta potential, particle size, and in vitro drug release analysis, demonstrated favorable results with a 93.69±3.72% release within 12 hours. Additionally, stability studies revealed that the preparation remained stable over a three-month period, indicating promising characteristics for potential application and storage

Keywords: Tamoxifen, Olive oil, Surfactants, FTIR studies, In vitro drug release studies