MOLECULAR AND BIOCHEMICAL PROFILING OF ANGIOTENSINCONVERTING ENZYME IN CLINICAL ISOLATES AND ITS CLINICALIMPLICATIONS IN DISEASEPROGNOSIS

Abstract

Angiotensin Converting Enzyme (ACE) plays a pivotal role in the renin-angiotensin-aldosterone system (RAAS) and has been implicated in various cardiovascular and renal diseases. This study  investigates the molecular and biochemical profiles of ACE in clinical isolates and explores its clinical implications in disease prognosis. Through a comprehensive review of literature, genetic variations, enzymatic activity, and expression levels of ACE have been analysed in diverse clinical populations. Furthermore, the association between ACE polymorphisms and disease susceptibility, severity, and response to treatment has been evaluated. The findings underscore the significance of ACE profiling in stratifying patients based on their genetic predisposition and biochemical status, thereby facilitating personalized medicine approaches. Moreover, the potential of ACE as a prognostic biomarker for disease progression and therapeutic response is discussed. Overall, this paper sheds light on the intricate interplay between ACE variability and clinical outcomes, paving the way for improved diagnostic and therapeutic strategies in cardiovascular and renal disorders.