A REVIEW OF THE PREVALENCE AND ANTI-FUNGAL RESISTANCE PROFILE OF CANDIDACAUSING CANDIDURIA IN PATIENTS WITH DIABETES

Abstract

It is estimated that around from 10-30% of people with diabetes also have a major case of candiduria in globally. According to 2019 predictions, there are 37 million people in India who are expected to have prediabetes and around 73 million people who have diabetes. Diabetes is the main risk factor for candiduria, this vulnerabel disease may lead to lower the immunity of an individule. Patients with low immunity favaour the Candida to cause infections   and also responsible for resistant of anti-fungal drugs. Therefore, Candiduria in DM patients have higher mortality rate. The purpose of this review is to figure out the overall incidence and resistance pattern of Candida in patients with diabetes mellitus.

Objectives:This study's objectives included a review of the incidence of candiduria in people with diabetes mellitus and the distribution of antifungal resistance, and the identification of candiduria risk factors.

Methodology:Multiple search engines (PubMed, EMBASE, MEDLINE, and Google scholar) were used to conduct a thorough English language literature search. A total of 200 articles were extracted and 149 of them were selected for the study.

Results:Candida albicans (≥ 30%) was more prevalent followed by Candida glabrata(≥ 10%).  Fluconazole was exclusively effective against C. tropicalis, while the other half of the C. albicans species were all susceptible to it.

Conclusion:Identifying the species of Candida correctly is crucial in these complicated situations to choose the most effective antifungal therapy.Therefore, to aid physicians in providing patients with candiduria with better care, it is important to regularly identify the species of Candida and their pattern of susceptibility to antifungals.